UK B. burgdorferi strains

Isolation and characterization of Borrelia burgdorferi strains from Ixodes ricinus ticks in southern England Sorouri R, Ramazani A, Karami A, Ranjbar R, Guy EC. Bioimpacts. 2015;5(2):71–8. Full text available from http://bi.tbzmed.ac.ir/JournalIssues/AllIssues/Volume5Issue2/2201552.aspx LDA was intrigued to come across this paper which was published in the current issue of the open access, multidisciplinary peer reviewed journal Bioimpacts, [...]

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Hope ahead?

Drug Combinations against Borrelia burgdorferi Persisters In Vitro : Eradication Achieved by Using Daptomycin , Cefoperazone and Doxycycline Feng J, Auwaerter PG, Zhang Y. PLoS One. 2015;1–15. Full text available from http://dx.doi.org/10.1371/journal.pone.0117207 What problem does this address? Some patients who have been treated for Lyme borreliosis with courses of standard antibiotics such as doxycycline, amoxicillin [...]

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Is persisting Bb infectious?

Cathy Rubin of the Huffington Post has interviewed Monica Embers about her team’s studies of Borrelia burgdorferi in rhesus macaque monkeys. This is a very good summary, with key references, of what we do and don’t know in this field. Monica Embers says: “While we have shown that intact Borrelia spirochetes can persist following a [...]

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Borreliosis: not just Lyme

Human Borrelia miyamotoi infection in the United States. Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. N Eng J Med 2013 Jan 17; 368(3):291-3. Introduction On 17th January 2013 news from America announced the discovery of ‘a new tick-borne infection that shares many similarities with Lyme disease’(1). [...]

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Longer treatment: better outcome

‘Management of suspected Lyme borreliosis: experience from an outpatient antibiotic therapy service.’ White B, Seaton RA, Evans TJ. QJM 2013; 106:133–38. Lyme disease in a Glasgow ID Clinic This study looks at the ‘real world experience’ of an infectious diseases clinic in Glasgow using Outpatient Parenteral Antibiotic Treatment (OPAT), in the form of intravenous ceftriaxone, [...]

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Lyme disease in a British referral clinic

A paper published earlier this year has already become widely quoted and so it is worth a brief comment to put this in perspective. Lyme disease in a British referral clinic Cottle, Mekonnen, Beadsworth, Miller & Beeching. QJM: Monthly Journal of the Association of Physicians June 2012 The paper describes the patterns of referral, investigation, [...]

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